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Biosketch
EDUCATION:
- PhD (2008-2014): Thesis title - Characterization of Host Protein Interactions with Hepatitis C Virus (HCV) RNA: Implications in Viral Translation, Replication, and Design of Antivirals
Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru - MSc (2005-2007): Biochemistry
Karnatak University, Dharwad - BSc (2002-2005): Physics, Chemistry, and Mathematics
Karnatak University, Dharwad
WORK EXPERIENCE:
- Assistant Professor (2024-Present): Department of Biosciences and Engineering, IIT Palakkad
- Research Scientist (2021-2024): Investigated host-virus interactions crucial for the influenza A virus life cycle; studied the molecular mechanism of mRNA export from the nucleus to the cytoplasm
Department of Cell Biology, UT Southwestern Medical Center, Dallas, USA - Postdoctoral Fellow (2016-2021): Studied host-virus interactions essential for the influenza A virus life cycle; discovered a small molecule that inhibits influenza A virus infection
Department of Cell Biology, UT Southwestern Medical Center, Dallas, USA - Postdoctoral Fellow (2015-2016): Investigated tumor suppressor functions of Ras Association Domain Family Member 10 (RASSF10)
Indian Institute of Technology Madras, Chennai - Project Assistant (2007-2008): Assisted researchers studying cell division in Mycobacterium
Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru
- PhD (2008-2014): Thesis title - Characterization of Host Protein Interactions with Hepatitis C Virus (HCV) RNA: Implications in Viral Translation, Replication, and Design of Antivirals
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Research
PUBLICATIONS:
1. Bhat P, Aksenova V, Gazzara M, Rex EA, Aslam S, Haddad C, Gao S, Esparza M, Cagatay T, Batten K et al (2023) Influenza virus mRNAs encode determinants for nuclear export via the cellular TREX-2 complex. Nat Commun 14: 2304
2. Bhat P, Shwetha S, Sharma DK, Joseph AP, Srinivasan N, Das S (2015) The beta hairpin structure within ribosomal protein S5 mediates interplay between domains II and IV and regulates HCV IRES function. Nucleic Acids Res 43: 2888-2901
3. Bhat P, Gnanasundram SV, Mani P, Ray PS, Sarkar DP, Das S (2012) Targeting ribosome assembly on the HCV RNA using a small RNA molecule. RNA Biol 9: 1110-1119
4. Xie Y, Gao S, Zhang K, Bhat P, Clarke BP, Batten K, Mei M, Gazzara M, Shay JW, Lynch KW et al (2023) Structural basis for high-order complex of SARNP and DDX39B to facilitate mRNP assembly. Cell Rep 42: 112988
5. Esparza M, Bhat P, Fontoura BM (2022) Viral-host interactions during splicing and nuclear export of influenza virus mRNAs. Curr Opin Virol 55: 101254
6. White K, Esparza M, Liang J, Bhat P, Naidoo J, McGovern BL, Williams MAP, Alabi BR, Shay J, Niederstrasser H et al (2021) Aryl Sulfonamide Inhibits Entry and Replication of Diverse Influenza Viruses via the Hemagglutinin Protein. J Med Chem 64: 10951-10966
7. Thompson MG, Dittmar M, Mallory MJ, Bhat P, Ferretti MB, Fontoura BM, Cherry S, Lynch KW (2020) Viral-induced alternative splicing of host genes promotes influenza replication. Elife 9
8. Aksenova V, Smith A, Lee H, Bhat P, Esnault C, Chen S, Iben J, Kaufhold R, Yau KC, Echeverria C et al (2020) Nucleoporin TPR is an integral component of the TREX-2 mRNA export pathway. Nat Commun 11: 4577
9. Thompson MG, Munoz-Moreno R, Bhat P, Roytenberg R, Lindberg J, Gazzara MR, Mallory MJ, Zhang K, Garcia-Sastre A, Fontoura BMA et al (2018) Co-regulatory activity of hnRNP K and NS1-BP in influenza and human mRNA splicing. Nat Commun 9: 2407
10. Kumar A, Das S, Mullick R, Lahiri P, Tatineni R, Goswami D, Bhat P, Torresi J, Gowans EJ, Karande AA et al (2016) Immune responses against hepatitis C virus genotype 3a virus-like particles in mice: A novel VLP prime-adenovirus boost strategy. Vaccine 34: 1115-1125
11. Khan D, Bhat P, Das S (2014) HCV-like IRESs sequester eIF3: advantage virus. Trends Microbiol 22: 57-58
12. Joseph AP, Bhat P, Das S, Srinivasan N (2014) Re-analysis of cryoEM data on HCV IRES bound to 40S subunit of human ribosome integrated with recent structural information suggests new contact regions between ribosomal proteins and HCV RNA. RNA Biol 11: 891-905
